Pergolide mesylate (By mouth)


Pergolide Mesylate (PER-goe-lide MES-i-late)

Treats Parkinson's disease. This medicine was withdrawn from the U.S. market in March 29, 2007, due to an increased chance of serious damage to heart valves.

Brand Name(s)

When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may take your medicine with food to avoid stomach upset.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using droperidol (Inapsine®), metoclopramide (Reglan®), phenothiazines (such as Compazine®, Mellaril®, Phenergan®, Serentil®, Tacaryl®, Thorazine®, Trilafon®), or medicine to treat mental illness (such as Haldol®, Navane®, Taractan®, thiothixene).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have breathing problems or heart rhythm or heart valve problems.
  • This medicine may make you dizzy or drowsy. These effects may be either mild or severe.
  • Some people using this medicine have become so drowsy they have fallen asleep during routine daily activities. Severe drowsiness or sleepiness may come on very suddenly. These effects may also occur even after you have been using the medicine for several months.
  • Make sure you know how this medicine affects you before you drive, use machines, or do anything else that could be dangerous if you are not alert. Tell your doctor if you think this medicine is causing you to have severe drowsiness or sleepiness.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Falling asleep during the day while you are driving, talking, eating, dressing, or doing any other routine activity.
  • Fast, pounding, or irregular heartbeat.
  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw).
  • Lightheadedness or fainting.
  • Rapid weight gain.
  • Severe confusion, seeing or hearing things that are not there (hallucinations).
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Swelling in your hands, ankles, or feet.

If you notice these less serious side effects, talk with your doctor:

  • Changes in vision.
  • Headache, muscle or joint pain.
  • Nausea, constipation, or diarrhea.
  • Problems with urination.
  • Runny nose.
  • Stomach upset.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.