Exenatide (By injection)


Exenatide (ex-EN-a-tide)

Treats type 2 diabetes.

Brand Name(s)

BYDUREON Pen, BYDUREON Single Dose Tray, Byetta

When This Medicine Should Not Be Used

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is given into your stomach, thigh, or upper arm.
  • Bydureon® is given 1 time each week. Byetta® is given 2 times each day. Bydureon® is an extended-release form of Byetta®. Do not use both medicines together.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use Bydureon® immediately once the powder has been dissolved and transferred to the syringe. The mixture should be off-white or cloudy.
  • Use a new needle and syringe each time you inject your medicine.
  • Never share medicine pens, needles, or syringes. There is a risk of infection if needles, pens, or syringes are used by more than one person.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose:
    • Bydureon®: Use this medicine as soon as you remember, as long as your next dose is due at least 3 days later. Skip the missed dose and go back to your regular dosing schedule if your next dose is due 1 or 2 days later. Do not use 2 doses of this medicine fewer than 3 days apart.
    • Byetta®: Skip the missed dose and inject your next regular dose. Never inject a missed dose after a meal.
  • Storage instructions:
    • Bydureon®: Store your medicine in the refrigerator, in the original carton, and protect it from light. Do not freeze it. Do not use the medicine if the expiration date has passed. If needed, you may store the single-dose trays at room temperature for up to 4 weeks.
    • Byetta®: Store your new, unused medicine pen in the refrigerator, in the original carton, and protect it from light. Do not freeze it. You may store the opened medicine pen in the refrigerator or at room temperature for 30 days. Remove the needle from the pen before you store the medicine. This prevents medicine from leaking and air bubbles from forming in the pen. Throw away the pen after you use it for 30 days, even if it still has medicine in it.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not use prandial insulin while you use Byetta®.
  • Take antibiotics or birth control pills at least 1 hour before you inject Byetta®.
  • Tell your doctor if you are using other diabetes medicine (such as insulin, glimepiride, glipizide, or glyburide), or if you take warfarin.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have gallstones, digestion problems (such as gastroparesis), a thyroid tumor, pancreas problems, kidney problems, or you had a kidney transplant.
  • This medicine may cause the following problems:
    • An increased risk of thyroid tumor
    • Pancreatitis
    • Low blood sugar (when used with other diabetes medicine)
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate, lower back or side pain, blood in your urine
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness

If you notice these less serious side effects, talk with your doctor:

  • Feeling tired or weak
  • Headache
  • Mild nausea, constipation, diarrhea, or upset stomach
  • Redness, itching, bump, swelling, or any changes in your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 10/4/2017

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