Ropinirole (By mouth)


Ropinirole (roe-PIN-i-role)

Treats symptoms of Parkinson's disease. Also treats restless legs syndrome (RLS).

Brand Name(s)

Requip, Requip XL

When This Medicine Should Not Be Used

How to Use This Medicine

Long Acting Tablet, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • You may take this medicine with or without food. You may take this medicine with food if it upsets your stomach.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • The dose of this medicine is different depending on whether you have Parkinson's disease or RLS. People who have Parkinson's usually take more medicine. Make sure you understand how much to take.

If a dose is missed:

  • For Parkinson's disease: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • For RLS: If you miss a dose or forget to use your medicine, use it as soon as you can if it is still the same day. If it is the next day, skip the missed dose, and take your next dose at the usual time. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Make sure your doctor knows if you are also taking ciprofloxacin (Cipro®), haloperidol (Haldol®), levodopa (Sinemet®), metoclopramide (Reglan®), thiothixene (Navane®), or a phenothiazine (such as Compazine®, Phenergan®, or Thorazine®).
  • Tell your doctor if you start or stop using estrogen. This includes birth control pills or medicine to treat menopause symptoms.
  • Do not drink alcohol while you are using this medicine.
  • Make sure your doctor knows if you smoke cigarettes.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you plan to become pregnant. Tell your doctor if you have a sleep disorder, eye problem, heart or heart rhythm problem, kidney disease, liver disease, blood pressure problem, lung disease, severe mental illness, history of skin cancer, or dyskinesia (trouble controlling your muscles).
  • This medicine could make you sleepy (more common in Parkinson's treatment). Some people have fallen asleep while doing everyday activities, such as driving. This problem could start any time during the first year of use, sometimes without warning. Be very careful, or avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. Talk to your doctor if this medicine makes you too sleepy. Drinking alcohol will add to your drowsiness.
  • When you first start using this medicine or if your dose is increased, you might feel dizzy, lightheaded, hot, or sick to your stomach if you stand up quickly. Get up slowly to give your body some time to adjust, especially if you have been sitting or lying down for a long time.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. If you need to stop using this medicine, talk to your doctor before starting to use it again.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Your doctor may also need to check your skin regularly. Be sure to keep all appointments.
  • Some people who have used this medicine had hallucinations or unusual changes in their behavior, such as having problems with gambling or an increased sex drive. Talk with your doctor if this is a concern for you.
  • Call your doctor if your symptoms do not improve or if they get worse. For RLS, the symptoms might get worse in the early morning, start earlier in the afternoon, or spread to your arms. For Parkinson's, you might have new or worse muscle movements.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, or painful urination.
  • Changes in vision.
  • Chest pain.
  • Extreme sleepiness or drowsiness.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, fainting, or falling.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Problems with balance or walking.
  • Seeing, hearing, or feeling things that are not really there.
  • Slow or fast heartbeat.
  • Swelling in your hands, legs, ankles, or feet.
  • Tremors, muscle stiffness, or slowed movements.
  • Twitching or muscle movements you cannot control.
  • Unusual behavior or urges.
  • Unusual tiredness or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Anxiety, nervousness, or trouble sleeping.
  • Confusion or memory problems.
  • Dry mouth.
  • Headache.
  • Increased appetite for food or sex.
  • Increased sweating.
  • Joint pain.
  • Nausea, vomiting, diarrhea, constipation, or stomach pain or upset.
  • Pain in arms or legs.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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