Rifampin (By injection)

Introduction

Rifampin (rif-AM-pin)

Treats tuberculosis (TB). This medicine is an antibiotic.

Brand Name(s)

Rifadin IV, Rifadin IV Novaplus

When This Medicine Should Not Be Used

How to Use This Medicine

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not receive this medicine if you also take medicine to treat HIV/AIDS, including atazanavir, darunavir, fosamprenavir, ritonavir, saquinavir, and tipranavir.
  • Some medicines can affect how rifampin works. Tell your doctor if you are using any of the following:
    • Atovaquone, clofibrate, cotrimoxazole, cyclosporine, dapsone, diazepam, digitoxin, digoxin, enalapril, haloperidol, halothane, levothyroxine, methadone, probenecid, quinine, sulfapyridine, sulfasalazine, tacrolimus, theophylline, or zidovudine
    • Birth control pills
    • Blood pressure medicine (including beta blockers, calcium channel blockers)
    • Blood thinner (including warfarin)
    • Medicine for heart rhythm problems (including disopyramide, mexiletine, quinidine, tocainide)
    • Medicine for seizures (including phenytoin)
    • Medicine to treat depression (including TCA)
    • Medicine to treat diabetes
    • Medicine to treat infections (including chloramphenicol, ciprofloxacin, clarithromycin, doxycycline, fluconazole, isoniazid, itraconazole, ketoconazole)
    • Narcotic pain reliever
    • Steroid medicine
  • If you use an antacid, take it at least 1 hour after you receive rifampin.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, or porphyria (an enzyme problem). Tell your doctor if you drink alcohol.
  • This medicine may cause the following problems:
    • Drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs, including the liver, kidney, or heart
    • Liver damage
  • This medicine may turn your urine, bowel movements, saliva, sweat, and tears red. This is normal. This side effect could stain contact lenses.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, chills, cough, sore throat, body aches
  • Numbness, pain, or tingling in your arms or legs
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache, dizziness
  • Mild nausea, vomiting, diarrhea, stomach pain
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 10/4/2017

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