Radiological Non-ionic contrast media (Injection)


Makes parts of your body show up better during an imaging test, such as an X-ray, CT scan, or MRI.

Brand Name(s)

Definity, Isovue Multipack-250, Isovue Multipack-300, Isovue Multipack-370, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M 200, Isovue-M 300, Magnevist, Novaplus Omniscan, Novaplus Visipaque, Omnipaque 140, Omnipaque 180

When This Medicine Should Not Be Used

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how it will be given. This medicine can be given different ways, depending on what part of your body the doctor needs to see. One way is through a needle or catheter (plastic tube) placed in one of your blood vessels.
  • A nurse or other health provider will give you this medicine.
  • You might also receive other medicines before you are given the contrast dye.
  • A caregiver might need to take your blood pressure, temperature, or pulse during the test.
  • Do not move around unless the person doing the test says it is okay. You might need to stay in one position, such as keeping your head up. If you do have to move, move slowly.
  • Ask your health caregiver if you need to drink extra water before or after the test.
  • You might need to stay at the hospital or clinic after the test is done. This will depend on what kind of test you are having.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows about all other medicines you are using. Different contrast dyes have different drug and food concerns. You might need to stop using some medicines for a short time, but do not stop unless your doctor tells you to. Some other things that affect other drugs and foods are what kind of test is being done and what part of your body is being tested.
  • Tell your health caregiver if you have recently received any other contrast dyes or medicines.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Make sure your doctor knows if you have severe kidney problems or liver disease. Also tell your doctor if you have just had a liver transplant or if you are going to have a transplant. The use of a gadolinium-based contrast agent (GBCA) during an MRI should be avoided in patients with severe kidney problems, patients with severe kidney problems due to a severe liver disorder (hepato-renal syndrome), or patients with severe kidney problems before, during, or after a liver transplant. The risk of nephrogenic systemic fibrosis (NSF), a very serious disease affecting the skin, muscle, and internal organs, may be increased. Your doctor may do some tests before your MRI to make sure your kidneys are working properly. Even if you have kidney problems or liver disease, your doctor may decide that it is still important to use the contrast dye. If you are on hemodialysis and treated with this contrast dye, your doctor may perform hemodialysis immediately after you receive the contrast agent.
  • Tell your doctor if you have high blood pressure, blood circulation problems, or congestive heart failure (CHF) or other heart disease. It is also important for your doctor to know if you have anemia or other blood cell problems, including sickle cell disease. Make sure your doctor knows if you have ever had a stroke or transient ischemic attack (TIA).
  • Make sure your health caregiver knows if you have diabetes, seizures, lung disease, thyroid problems, an infection, multiple sclerosis, or pheochromocytoma (a tumor on the adrenal gland). Tell your caregiver if you have cancer, especially if you have multiple myeloma.
  • Tell your doctor and the person who does the test if you are allergic to iodine, or if you have asthma or any type of allergy. This includes hay fever, drug allergy, and food allergy.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Ask your doctor if you need to call right away if you have pain after the test. For some tests, pain could be a sign of a problem, but for other tests pain is not a concern.
  • The specific test you are having could have its own side effects or risks. Talk with you health caregiver about the test and what you should expect during and after the test.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain.
  • Fever.
  • Lightheadedness or fainting.
  • Muscle stiffness or weakness, stiff joints or trouble moving, deep bone pain.
  • Seizure.
  • Severe nausea and vomiting.
  • Skin rash, swelling, hardness, tightness, burning, itching, or red or dark patches.
  • Slow or uneven heartbeat.
  • Sudden or severe headache.
  • Unusual muscle problems, unusual behavior, changes in vision.

If you notice these less serious side effects, talk with your doctor:

  • Mild pain or swelling where the needle was placed.
  • Mild skin burning, pain, or warm feeling when the dye is injected.
  • Nausea, vomiting, unusual taste in your mouth.
  • Warmth or redness in your face, neck, arms, or upper chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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