Rabeprazole (By mouth)


Rabeprazole (ra-BEP-ra-zole)

Treats heartburn, stomach ulcers, gastroesophageal reflux disease (GERD), esophagus damage, and conditions that cause your stomach to make too much acid, such as Zollinger-Ellison syndrome. This medicine may be used in combination with antibiotics to treat H pylori stomach infections and ulcers. This medicine is a proton pump inhibitor (PPI).

Brand Name(s)

Aciphex, Aciphex Sprinkle

When This Medicine Should Not Be Used

How to Use This Medicine

Delayed Release Capsule, Delayed Release Tablet

  • Take your medicine as directed.
  • Delayed-release capsule:
    • Take the capsule 30 minutes before a meal.
    • Open 1 capsule and pour the entire contents into a small amount of soft food (such as applesauce, fruit or vegetable baby food, yogurt) or a small amount of liquid (such as infant formula, apple juice, or pediatric electrolyte solution [Pedialyte®]). Swallow the mixture without chewing. The entire mixture should be taken within 15 minutes to make sure that you get the full dose. Do not save it for later use.
  • Delayed-release tablet:
    • Swallow the tablet whole with water. Do not chew, crush, or break it.
  • This medicine is sometimes given together with other medicines to treat ulcers. Make sure you understand how to use all of your medicines.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Digitek®, Lanoxin®), ketoconazole (Nizoral®), methotrexate (Rheumatrex®, Trexall®), an iron supplement, or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Do not take atazanavir (Reyataz®) with this medicine, unless your doctor says it is okay.
  • Tell your doctor if you also use a diuretic (water pill, such as furosemide, hydrochlorothiazide, torsemide, Lasix®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver problems, osteoporosis, or a history of low magnesium levels in your blood.
  • This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you take this medicine longer than 1 year, or if you take it with digoxin or certain diuretics (water pills). Tell your doctor right away if you have seizures, dizziness, a fast or pounding heartbeat, or muscle spasms.
  • You may be at risk for Clostridium difficile colitis (also called C diff) if you take this medicine. C diff is an inflammation of your large intestine that causes diarrhea. You have a higher risk of this condition if you also use an antibiotic, are elderly, or have other chronic conditions.This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • This medicine may increase your risk of broken bones in the hip, wrist, or spine. This is more likely if you are older than 50, if you take this medicine more than once a day, or if you use it for 1 year or longer.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dizziness
  • Fast, pounding, or uneven heartbeat
  • Muscle spasms, cramps
  • Seizures
  • Severe diarrhea that does not go away, stomach pain

If you notice these less serious side effects, talk with your doctor:

  • Fever, chills, cough, sore throat, and body aches
  • Headache
  • Mild diarrhea, constipation, gas, nausea, vomiting

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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