Protriptyline hydrochloride (By mouth)
Protriptyline Hydrochloride (proe-TRIP-ti-leen hye-droe-KLOR-ide)
Treats depression. This medicine is a tricyclic antidepressant.
When This Medicine Should Not Be Used
How to Use This Medicine
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- You may need to take this medicine for a few weeks before you begin to feel better.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
If a dose is missed:
- Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using cimetidine (Tagamet®), tramadol (Ultram?), medicine for heart rhythm problems (such as verapamil, Cardioquin®, Rythmol®, Sectral®, or Tambocor®), medicine for high blood pressure or thyroid problems, or other medicines to treat depression or mental illness.
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, diabetes, glaucoma, problems with urination, seizures, or thyroid disease.
- For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. All of the warnings in this leaflet are true for a child, teenager, or young adult who is using this medicine. Tell your doctor right away if you start to feel more depressed. Also tell your doctor right away if you have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure your caregiver knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let your doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Confusion, agitation, hallucinations, hostility, or other unusual behaviors.
- Excessive sleepiness.
- Fast or irregular heartbeat.
- Feeling anxious, restless, or irritable.
- Unusual behavior or thoughts of hurting yourself or others.
If you notice these less serious side effects, talk with your doctor:
- Dizziness or lightheadedness, especially when standing up.
- Nausea or vomiting.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 8/4/2014
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