Oxycodone/aspirin (By mouth)
Aspirin (AS-pir-in), Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)
Treats moderate to severe pain. This medicine contains a narcotic pain reliever and an NSAID.
When This Medicine Should Not Be Used
How to Use This Medicine
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.
- Drink plenty of liquids to help avoid constipation.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose:Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Do not throw unused medicine in the trash. Ask your pharmacist about the best way to dispose of medicine you do not use.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines and food can affect how oxycodone and aspirin work. Tell your doctor if you are also using any of the following:
- Acetazolamide, carbamazepine, erythromycin, ketoconazole, methotrexate, mirtazapine, phenytoin, probenecid, rifampin, ritonavir, sulfinpyrazone, tramadol, trazodone, or valproic acid
- Blood pressure medicine
- Blood thinner (including heparin or warfarin)
- Diuretic (water pill)
- Insulin or other diabetes medicine
- Medicine for depression or mental health problems
- NSAID pain or arthritis medicine (including celecoxib, diclofenac, ibuprofen, naproxen)
- Phenothiazine medicine
- Triptan medicine for migraine headaches
- Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, naltrexone, pentazocine, or a muscle relaxer.
- Do not drink alcohol while you are using this medicine. Do not take any medicine that contains alcohol.
Warnings While Using This Medicine
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, anemia, blood clotting problems, lung disease or breathing problems, circulation problems, stomach ulcers, Addison disease, enlarge prostate, trouble urinating, thyroid problems, or a history of head injury, seizures, pancreatitis, alcohol abuse or drug addiction.
- This medicine might cause the following problems:
- High risk of overdose, which can lead to death
- Respiratory depression (serious breathing problem that can be life-threatening)
- Kidney damage
- Liver damage
- Serotonin syndrome (when used with certain medicines)
- Do not give aspirin to a child or teenager who has chickenpox or flu symptoms, unless approved by a doctor. Aspirin can cause a life-threatening reaction called Reye syndrome.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Blistering, peeling, red skin rash
- Blue lips, fingernails, or skin
- Change in how much or how often you urinate
- Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
- Extreme weakness, shallow breathing, slow heartbeat, sweating, cold or clammy skin
- Lightheadedness, dizziness, fainting
- Severe stomach pain, vomiting blood, bloody or black, tarry stools
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Constipation, heartburn
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 10/4/2017
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