Omeprazole/sodium bicarbonate (By mouth)


Omeprazole (oh-MEP-ra-zole), Sodium Bicarbonate (SOE-dee-um bye-KAR-bo-nate)

Treats heartburn, stomach ulcers, gastroesophageal reflux disease (GERD), and damage to the esophagus. This medicine also helps prevent stomach bleeding in patients who have a serious illness. This medicine is a combination of a proton pump inhibitor (PPI) and an antacid.

Brand Name(s)

Rite Aid Omeprazole and Sodium Bicarbonate, Zegerid, Zegerid OTC

When This Medicine Should Not Be Used

How to Use This Medicine

Capsule, Packet

  • Take your medicine as directed.
  • Take this medicine on an empty stomach, at least 1 hour before you eat. Do not stop taking this medicine sooner than your doctor recommends, even if you feel better. Take this medicine only as directed.
    • Powder: Mix the powder with 1 to 2 tablespoons of water in a small cup and drink this mixture right away. Do not mix with other liquids or foods. Refill the cup with more water and drink it to make sure you get all of the medicine.
    • Capsule: Swallow the capsule whole with water. Do not mix with other liquids. Do not break, crush, or chew the capsule. Do not open the capsule and sprinkle the contents into food.
    • Feeding tube: Patients with feeding tubes should not receive food for 3 hours before and 1 hour after administration of Zegerid®.
      • Open the packet and mix the powder into about 20 mL of water. Stir or shake well. Do not mix with other liquids or foods.
      • Immediately administer the mixture into the feeding tube with an appropriately sized syringe.
      • All 20 mL of the mixture should be flushed through the tube. Refill the container with water, mix in the leftover medicine, and administer it to make sure all of the medicine is given to the patient.
  • Do not substitute the 20-milligram packets or capsules with the 40-milligram packets or capsules.
  • Tell your doctor if you are on a low-salt diet. This medicine contains sodium.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you use ampicillin (Principen®, Unasyn®), clarithromycin (Biaxin®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), ketoconazole (Nizoral®), methotrexate (Rheumatrex®, Trexall®), rifampin (Rifadin®, Rimactane®), St John's wort, tacrolimus (Prograf®), or voriconazole (Vfend®). Also, tell your doctor if you use disulfiram (Antabuse®), phenytoin (Dilantin®), an iron supplement, a blood thinner (such as warfarin, Coumadin®, Jantoven®), or a tranquilizer (such as alprazolam, diazepam, Valium®, Xanax®).
  • Make sure your doctor knows if you also use clopidogrel (Plavix®), digoxin (Lanoxin®), or a diuretic (water pill, such as bumetanide, chlorothiazide, ethacrynic acid, furosemide, hydrochlorothiazide, indapamide, metolazone, torsemide, Bumex®, Demadex®, Diuril®, Edecrin®, Lasix®, Lozol®, Zaroxolyn®). Tell your doctor if you also use medicine to treat HIV or AIDS, such as atazanavir (Reyataz®), nelfinavir (Viracept®), ritonavir (Norvir®), or saquinavir (Fortovase®, Invirase®).
  • Tell your doctor if you take calcium supplements regularly.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney problems (such as Bartter syndrome), liver disease, congestive heart failure, or osteoporosis. Your doctor will also need to know if you have a history of low levels of calcium, potassium, or magnesium in your blood.
  • People of Asian race may react differently to this medicine.
  • This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you take this medicine longer than 1 year or if you take it with digoxin or certain diuretics (water pills). Tell your doctor right away if you have seizures, dizziness, a fast or pounding heartbeat, or muscle spasms.
  • You may be at risk for Clostridium difficile colitis (also called C diff) if you take this medicine. C diff is an inflammation of your large intestine that causes diarrhea. You have a higher risk of this condition if you also use antibiotics, are elderly, or have other health conditions.This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • This medicine may increase your risk of broken bones in the hip, wrist, and spine. This is more likely if you are older than 50, if you receive high doses of this medicine, or you use it for longer than 1 year.
  • You may have more digestive problems if you take this medicine long-term. You may also notice swelling and weight gain. Talk with your doctor if you have any concerns.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You may need blood or other lab tests to check for side effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Decrease in how much or how often you urinate, pain when you urinate, fever, lower back or side pain
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Fast, slow, uneven, or pounding heartbeat
  • Lightheadedness, dizziness, or fainting
  • Seizures, muscle spasms, tremors
  • Severe diarrhea that does not go away, stomach pain, fever
  • Swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea or stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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