Morphine/naltrexone (By mouth)
Morphine Sulfate (MOR-feen SUL-fate), Naltrexone Hydrochloride (nal-TREX-one hye-droe-KLOR-ide)
Treats moderate to severe pain. This medicine contains a narcotic pain reliever.
When This Medicine Should Not Be Used
How to Use This Medicine
Long Acting Capsule
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time
- Swallow the extended-release capsule whole. Do not crush, break, or chew it.
- If you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of applesauce. Stir this mixture well and swallow it without chewing.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Do not throw unused medicine in the trash. Flush it down the toilet, or take it to a community take-back program if available.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how morphine/naltrexone works. Tell your doctor if you also are using any of the following:
- A diuretic (water pill)
- A phenothiazine medicine
- An MAO inhibitor (MAOI) within the past 14 days
- Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung or breathing problems (such as asthma or COPD), low blood pressure, pancreas problems, an enlarged prostate, trouble urinating, gallbladder problems, or stomach or digestion problems. Also tell your doctor if you have a history of depression, head injury, brain tumor, seizures, or drug or alcohol abuse.
- This medicine may cause the following problems:
- High risk of overdose, which can lead to death
- Respiratory depression (serious breathing problem that can be life-threatening)
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy, drowsy, or faint. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blue lips, fingernails, or skin
- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
- Severe confusion, lightheadedness, dizziness, fainting
- Severe constipation, stomach pain, or vomiting
- Trouble breathing or slow breathing
If you notice these less serious side effects, talk with your doctor:
- Mild constipation, nausea, or vomiting
- Mild sleepiness or tiredness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 8/4/2014
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