Linezolid (Injection)

Introduction

Linezolid (lin-AYZ-oh-lid)

Treats bacterial infections, including skin infections and pneumonia. This medicine is an antibiotic.

Brand Name(s)

Zyvox

When This Medicine Should Not Be Used

How to Use This Medicine

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you have used an MAO inhibitor (MAOI) in the past 14 days.
  • Some medicines and foods can affect how linezolid works. You should not receive this medicine if you are also using buspirone, dobutamine, dopamine, meperidine, cold medicines or decongestants (such as phenylpropanolamine, pseudoephedrine), medicine to treat depression (such as amitriptyline, doxepin, fluoxetine, nortriptyline, paroxetine), or medicine to treat migraine headaches (such as sumatriptan, zolmitriptan).
  • Avoid foods or drinks that contain tyramine. This includes aged cheeses, dried meats, sauerkraut, soy sauce, tap beers, or red wines.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have bone marrow problems, diabetes, thyroid problems, carcinoid syndrome, pheochromocytoma, or a history of high blood pressure or seizures.
  • This medicine may cause the following problems:
    • Lactic acidosis
    • Serotonin syndrome
    • Blurred vision or loss of vision
    • Severe diarrhea (may occur up to 2 months after you stop taking this medicine)
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Diarrhea that contains blood
  • Extreme weakness, tiredness, or confusion
  • Fever, chills, cough, sore throat, and body aches
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Rapid breathing, severe nausea and vomiting
  • Seizures
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Unusual bleeding or bruising
  • Vision changes

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea, diarrhea, or vomiting
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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