Lansoprazole (By mouth)


Lansoprazole (lan-SOE-pra-zole)

Treats stomach ulcers, gastroesophageal reflux disease (GERD), and conditions that cause your stomach to make too much acid. Also helps heal a damaged esophagus. This medicine is a proton pump inhibitor (PPI).

Brand Name(s)

First - Lansoprazole, Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid, Prevacid NapraPAC 375, Prevacid NapraPAC 500, Prevacid SoluTab, Prevacid Solutab, Prevpac, Rite Aid Lansoprazole, Topcare Lansoprazole, Triple Therapy

When This Medicine Should Not Be Used

How to Use This Medicine

Delayed Release Capsule, Liquid, Tablet Disintegrating, Delayed Release, Packet

  • Take your medicine as directed.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Take this medicine before you eat and for the full time of treatment, even if you begin to feel better after a few days.
  • Capsule: Swallow the capsule whole. Do not break, crush, or chew it.
    • If you cannot swallow the capsule, you may open it and put the contents onto 1 tablespoon of applesauce, EnsureĀ® pudding, cottage cheese, yogurt, or strained pears. You may also use 60 mL (1/4 cup) apple, orange, or tomato juice. Swallow this mixture right away without chewing. If you used juice, refill the cup 2 more times with juice and drink the remaining mixture.
  • Tablet: Dry your hands before you handle the tablet. Do not crush, chew, break, or cut the tablet. Place the tablet on your tongue and allow it to dissolve. Swallow the particles right away.
  • Tablet with an oral syringe: Dry your hands before you handle the tablet. Do not crush, chew, break, or cut the tablet.
    • 15-milligram tablet: Place the tablet in the oral syringe and add 4 mL (1 teaspoon) of water.
    • 30-milligram tablet: Place the tablet in the oral syringe and add 10 mL (2 teaspoons) of water.
    • Shake the syringe gently until the tablet dissolves and is mixed well.
    • Use the mixture within 15 minutes.
    • Refill the syringe with water. Use 2 mL (1/2 teaspoon) water for the 15-milligram tablet, or 5 mL (1 teaspoon) for the 30-milligram tablet. Shake the syringe gently. Give the mixture to make sure all of the medicine is taken.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how lansoprazole works. Tell your doctor if you are also using any of the following:
    • Ampicillin
    • Atazanavir
    • Digoxin
    • Ketoconazole
    • Tacrolimus
    • Theophylline
    • Diuretic (water pill)
    • Blood thinner (such as warfarin)
    • Iron supplement
  • If you also take sucralfate, take lansoprazole 30 minutes before you take sucralfate.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, osteoporosis, seizures, or phenylketonuria (PKU).
  • This medicine may cause the following problems:
    • Hypomagnesemia (low magnesium in the blood)
    • Increased risk of broken bones in the hip, wrist, or spine
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Fast or uneven heartbeat
  • Seizures, dizziness, muscle spasms or cramps, weakness
  • Severe diarrhea that does not go away, stomach pain, fever

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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