Insulin glargine (Injection)


Insulin Glargine, Recombinant (IN-su-lin GLAR-jeen, ree-KOM-bi-nant)

Treats diabetes.

Brand Name(s)

Lantus, Lantus SoloStar

When This Medicine Should Not Be Used

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. If you use insulin once a day, it is best to use it at about the same time every day.
  • You will be taught how to give your medicine at home. Make sure you understand all instructions.
  • This medicine should look clear before you use it. Do not shake the vial. Do not mix this medicine with any other insulin or with water.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Use only syringes that are made for insulin. Some types of insulin must be used with a certain type of syringe or needle. Ask your pharmacist if you are not sure which one to use.
  • When you get a new supply of insulin, check the label to be sure it is the correct type.
  • Missed dose: Call your doctor or pharmacist for instructions.
  • Unopened medicine: Store the vials, cartridges, or SoloStar┬« pen in the refrigerator. Protect from light. Do not freeze.
  • Opened medicine that is currently being used:
    • Vials: Store in the refrigerator or at room temperature in a cool place, away from sunlight and heat. Use within 28 days.
    • Cartridge or SoloStar┬« pen: Store at room temperature, away from direct heat and light. Do not refrigerate. Throw away any opened cartridge or pen after 28 days.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how insulin glargine works. Tell your doctor if you are using any of the following:
    • Albuterol, aspirin, danazol, clonidine, clozapine, disopyramide, epinephrine, fluoxetine, glucagon, guanethidine, isoniazid, lithium, niacin, olanzapine, pramlintide, pentamidine, pentoxifylline, propoxyphene, reserpine, somatropin, or terbutaline.
    • ACE inhibitors, beta-blockers, birth control pills, diuretics (water pills), MAO inhibitors (MAOI), medicine to lower cholesterol, medicine to treat HIV/AIDS, a phenothiazine medicine, somatostatin drugs (such as lanreotide or octreotide), steroid medicine, sulfa drugs, or thyroid medicine.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure. Tell your doctor if you drink alcohol.
  • This medicine may cause the following problems:
    • Low blood sugar
    • Fluid retention or heart failure (when used with thiazolidinedione [TZD] medicine)
  • Never share insulin pens or cartridges with anyone. Shared needles or pens can pass hepatitis viruses, HIV, or other illnesses from one person to another.
  • Hyperglycemia (high blood sugar) may occur if you do not take this medicine correctly.
  • Your doctor may change your insulin dose for diet or activity changes, illness, pregnancy, or other conditions that stress your body.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Shaking, trembling, sweating, lightheadedness, fast or pounding heartbeat
  • Confusion, restlessness, headache, hunger, slurred speech, vision changes
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Trouble breathing, tiredness, or bluish-colored skin

If you notice these less serious side effects, talk with your doctor:

  • Redness, pain, itching, burning, swelling, or a lump under your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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