Treats mild to severe pain. Also used to treat fever in adults. This is a nonsteroidal antiinflammatory medicine (NSAID).
When This Medicine Should Not Be Used
How to Use This Medicine
- Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
- A nurse or other health provider will give you this medicine.
- Drink extra fluids so you will urinate more often and help prevent kidney problems.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using aspirin, a blood thinner (such as warfarin, Coumadin®), a steroid medicine (such as dexamethasone, prednisolone, prednisone, or Medrol®), or a diuretic or "water pill" (such as furosemide, hydrochlorothiazide [HCTZ], torsemide, Demadex®, or Lasix®).
- Do not use any other NSAID medicine unless your doctor says it is okay. Some other NSAID medicines are naproxen, Advil®, Aleve®, Celebrex®, Ecotrin®, and Motrin®.
- Make sure your doctor knows if you are also using lithium (Eskalith®), methotrexate (Rheumatrex®), or medicine to lower blood pressure (such as enalapril, lisinopril, Accupril®, Lotrel®, or Zestril®).
Warnings While Using This Medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding or have kidney disease, liver disease, anemia, bleeding problems, high blood pressure, congestive heart failure (CHF), systemic lupus erythematosus (SLE), or a history of stomach ulcers or bleeding.
- This medicine may increase your risk of having a heart attack or stroke. This is more likely to occur in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.
- This medicine might cause bleeding in your stomach or intestines. This is more likely to occur if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (such as steroids or a blood thinner).
- Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.
- This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you get the injection.
- Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; a severe skin rash or acne; sores or ulcers on the skin; or fever or chills while you are using this medicine.
- Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after you receive this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
- Call your doctor right away if you have confusion, drowsiness, fever, a general feeling of illness, a headache, loss of appetite, nausea, stiff neck or back, or vomiting. These could be symptoms of a serious condition called meningitis.
- Tell your doctor if you have unexplained weight gain or edema (fluid retention or body swelling) with this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash.
- Change in how much or how often you urinate.
- Chest pain or coughing up blood.
- Dark-colored urine or pale stools.
- Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
- Fever, chills, cough, sore throat, and body aches.
- Lightheadedness or fainting.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Rapid weight gain.
- Shortness of breath, cold sweats, and bluish-colored skin.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding, bruising, or weakness.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, stomach upset or pain.
- Headache or dizziness.
- Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 8/4/2014
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