Human papillomavirus vaccine, quadrivalent (Injection)


Human Papillomavirus Recombinant Vaccine Quadrivalent (Types 6, 11, 16, 18) (HUE-man pap-ah-LOH-mah-VYE-rus ree-KOM-bi-nant VAX-een kwa-drah-VAY-lent (types 6,11,16,18))

Prevents cancer, genital warts, and abnormal or precancerous diseases of the anus, cervix, vagina, or vulva caused by 4 specific types of human papillomavirus (HPV), in girls and women 9 to 26 years of age. Also prevents abnormal or precancerous diseases of the anus, anal cancer, and genital warts in boys and men 9 to 26 years of age.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other health provider will give you this medicine.
  • This vaccine must be given as 3 doses. After the first dose, two more doses are given at 2 months and 6 months later, unless your doctor tells you otherwise.

If a dose is missed:

  • This vaccine needs to be given on a fixed schedule. If you miss your scheduled shot, call your doctor to make another appointment as soon as possible.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are receiving a treatment or using a medicine that causes a weak immune system. This may include radiation treatment, steroid medicines (such as cortisone, dexamethasone, prednisone, Cortef®, or Medrol®), or cancer medicines (such as cyclophosphamide, doxorubicin, etoposide, Adriamycin®, or Cytoxan®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a weak immune system because of a disease (such as HIV infection or a genetic defect) or a medicine (such as steroids). Tell your doctor if you have an active infection that is causing fever or chills.
  • This vaccine will not treat anal or cervical cancer, genital warts, or other diseases caused by HPV. It will not protect you against diseases that are caused by HPV types not in the vaccine. This vaccine will not protect you against diseases that are not caused by HPV.
  • This vaccine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, swelling of the tongue and throat, or trouble with breathing after you get the injection.
  • This vaccine does not replace your routine screening tests for anal cancer or cervical cancer (pap test). You will need to see your doctor for screening tests even after receiving this vaccine.
  • You may feel faint, lightheaded, or dizzy right after you receive this vaccine. Sitting or lying down for 15 minutes after you receive the vaccine may help. If any of these side effects occur, do not drive, use machines, or do anything else that could be dangerous if you are not alert. If this problem continues or gets worse, check with your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, shortness of breath, or coughing up blood.
  • Fever, chills, runny or stuffy nose, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Numbness, weakness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Pain in your lower leg (calf).
  • Seizures.
  • Sudden and severe stomach pain, nausea, or vomiting.
  • Swollen glands in your neck, armpit, or groin.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Headache.
  • Joint or leg pain.
  • Pain, redness, itching, burning, swelling, or a lump under your skin where the shot is given.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.