Dasatinib (By mouth)
When This Medicine Should Not Be Used
How to Use This Medicine
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Swallow the tablet whole. Do not crush, break, or chew it.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some foods and medicines can affect how dasatinib works. Tell your doctor if you are using alfentanil, carbamazepine, cisapride, cyclosporine, dexamethasone, doxorubicin, fentanyl, nefazodone, phenobarbital, phenytoin, pimozide, quinidine, rifabutin, rifampicin, simvastatin, sirolimus, tacrolimus, ergotamine medicine (such as dihydroergotamine, ergotamine), or St John's wort.
- Also tell your doctor if you are using medicine to treat an infection (such as clarithromycin, erythromycin, telithromycin, itraconazole, ketoconazole, voriconazole), medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir), a blood thinner (such as warfarin or aspirin), or heartburn or stomach medicine (such as cimetidine, esomeprazole, famotidine, lansoprazole, omeprazole, pantoprazole, rabeprazole, or ranitidine).
- If you use an antacid, take it at least 2 hours before or 2 hours after you take dasatinib.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Pregnant women should not handle crushed or broken tablets. Wear disposable gloves if you need to handle broken tablets.
- Tell your doctor if you are breastfeeding, or if you have a blood disorder such as anemia, bleeding problems, heart disease, heart rhythm problems, low potassium or magnesium levels in your blood, problems with fluid retention (edema), or if you are lactose intolerant.
- This medicine can cause the following problems:
- Heart or heart rhythm problems
- High blood pressure in your lungs (pulmonary arterial hypertension)
- Fluid retention
- Low blood cell counts
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Chest pain, trouble breathing, fast, pounding, or uneven heartbeat
- Fever, chills, cough, runny or stuffy nose, sore throat, body aches
- Lightheadedness, dizziness, fainting
- Rapid weight gain, swelling in your hands, ankles, or feet
- Red or black, tarry stools
- Severe stomach pain
- Unusual bleeding, bruising, or weakness
- Vomiting blood or material that looks like coffee grounds
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, nausea, vomiting, or stomach pain
- Muscle or joint pain
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 8/4/2014
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