Clomipramine (By mouth)


Clomipramine (kloe-MIP-ra-meen)

This medicine is a tricyclic antidepressant that treats obsessive-compulsive disorder.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine

Capsule, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Your doctor may tell you to take the medicine at bedtime to prevent drowsiness during the day.
  • It is best to take this medicine with food or milk.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not take this medicine with an MAO inhibitor (MAOI), or if you have taken an MAOI in the past 14 days.
  • Some medicines and foods can affect how clomipramine works. Tell your doctor if you are taking any of the following:
    • Buspirone, cimetidine, clonidine, digoxin, fentanyl, guanethidine, haloperidol, lithium, methylphenidate, St John's wort, tryptophan
    • A blood thinner (such as warfarin), depression medicine (such as fluoxetine, fluvoxamine, paroxetine, sertraline), heart rhythm medicine (such as flecainide, propafenone, quinidine), pain or migraine medicine (such as tramadol), phenothiazine medicine (such as promethazine), seizure medicine (such as phenobarbital, phenytoin), thyroid medicine
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding.
  • Tell your doctor if you have liver disease, an adrenal gland tumor (such as neuroblastoma), glaucoma, heart disease, depression, mood or mental problems, an overactive thyroid, trouble urinating, or a history of seizures.
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Tell your doctor if you or anyone in your family has bipolar disorder or has tried to commit suicide.
  • This medicine may make you dizzy or drowsy. Do not drive or use machines until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Agitation, anxiety, confusion, depression, irritability, memory problems, trouble sleeping
  • Anxiety, restlessness, or seeing or hearing things that are not there
  • Change in how much or how often you urinate, painful or difficult urination
  • Chest pain or a fast, pounding heartbeat
  • Increased sweating, warmth or redness in your face, neck, arms, or upper chest
  • Lightheadedness, dizziness, fainting
  • Seizures or tremors
  • Unusual behavior or thoughts of hurting others or yourself
  • Unusual bleeding, bruising, or weakness
  • Unusual drowsiness or sleepiness

If you notice these less serious side effects, talk with your doctor:

  • Changes in vision or taste, dry mouth
  • Cough, sore throat, runny or stuffy nose
  • Nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain or upset
  • Problems with ejaculation or decreased sexual performance
  • Skin rash or itching
  • Weight gain or loss

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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