Clindamycin/tretinoin (On the skin)
Clindamycin (klin-da-MYE-sin), Tretinoin (TRET-i-noin)
When This Medicine Should Not Be Used
How to Use This Medicine
- Take your medicine as directed.
- This medicine is for use on the skin only. Do not get it in your eyes, mouth, nose, on the corners of your nose, or vagina. Do not use it on skin areas that have cuts or scrapes. If it does get on these areas, rinse it off right away.
- It is best to use this medicine at bedtime.
- Wash your hands with soap and water before and after you use this medicine.
- Before applying this medicine, wash your face with warm water and a mild soap, rinse well, and pat dry.
- Apply a thin layer of the medicine to the affected area. Rub it in gently.
- You may need to use this medicine for several weeks or months before your skin starts to look better. Applying extra medicine will not make it work faster.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
If a dose is missed:
- Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using erythromycin (Akne-Mycin®, A/T/S®, E-Mycin®, Eryderm®, Ery-tab®) or muscle relaxants (such as pancuronium, vecuronium, Norcuron®, or Pavulon®).
- Do not use any other medicines on the treated skin areas without asking your doctor. Avoid using any skin care products that can dry or irritate your skin. These include rough skin cleansers, soaps, or products that contain alcohol, spices, or lime.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you are planning to have a surgery.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- This medicine may make your skin more sensitive to sunlight, wind, and cold weather. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. You may need to wear protective clothing, such as a hat.
- Skin reactions can occur when you use this medicine, such as dryness, redness, peeling, burning, or stinging. Stop using this medicine and call your doctor right away if your skin becomes very red, swollen, blistered, or crusted.
- This medicine may also cause a temporary change in skin color (lighter or darker). Talk to your doctor if this concerns you.
- Do not use this medicine to treat a skin problem your doctor has not examined.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Diarrhea that is watery or contains blood.
- Severe or ongoing skin redness, peeling, itching, blistering, crusting, or swelling.
If you notice these less serious side effects, talk with your doctor:
- Changes in skin color.
- Headache, cough, sore throat, or runny or stuffy nose.
- Mild skin dryness, itching, peeling, burning, or redness.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 8/4/2014
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