Carbidopa/levodopa/entacapone (By mouth)


Carbidopa (kar-bi-DOE-pa), Entacapone (en-TAK-a-pone), Levodopa (lee-voe-DOE-pa)

Treats symptoms of Parkinson disease.

Brand Name(s)

Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75

When This Medicine Should Not Be Used

How to Use This Medicine

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may take this medicine with or without food. Do not crush, chew, or break the tablet. Swallow it whole.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not take this medicine if you are also taking isocarboxazid, phenelzine, or tranylcypromine.
  • Some medicines and foods can affect how this medicine works. Tell your doctor if you are taking any of the following:
    • Cholestyramine, isoniazid, methyldopa, metoclopramide, papaverine, phenytoin, probenecid, risperidone, selegiline
    • Antibiotics (such as erythromycin, rifampicin, ampicillin, chloramphenicol), blood pressure medicine (such as amlodipine, atenolol, clonidine, hydrochlorothiazide [HCTZ], lisinopril, metoprolol, olmesartan), depression medicine (such as amitriptyline, doxepin, nortriptyline), a phenothiazine medicine (such as promethazine, chlorpromazine), vitamin supplements that contain iron
  • Do not eat high-protein foods while you are taking this medicine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, low blood pressure, kidney, liver, or lung disease, gallstones, glaucoma, a stomach ulcer, or endocrine system problems (such as diabetes or thyroid problems). Tell your doctor if you have a history of mental or emotional problems, or if you had a heart attack.
  • Tell any doctor or dentist who treats you that you are taking this medicine. This medicine may affect the results of certain medical tests, including tests often used by people who have diabetes. It may also affect medicines that are used during an emergency or surgery.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell your doctor if your Parkinson symptoms start to come back between doses.
  • This medicine may make you dizzy. Stand up slowly. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • This medicine might cause your saliva, sweat, or urine to become dark red, brown, or black. This is nothing to worry about, but it could stain your clothes.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Depression, thoughts of hurting yourself
  • Hallucinations (seeing or hearing things that are not truly there), confusion
  • Fever, sweating, severe muscle pain or stiffness, uneven heartbeat
  • Lightheadedness, dizziness, fainting, fast heartbeat
  • Repetitive movements you cannot control (either new or worse than usual)
  • Severe diarrhea
  • Trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea, nausea, stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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