Bupropion (By mouth)


Bupropion (bue-PROE-pee-on)

Treats depression and aids in quitting smoking. Also prevents depression caused by seasonal affective disorder (SAD).

Brand Name(s)

Aplenzin, Appbutamone, Appbutamone-D, Budeprion SR, Budeprion XL, Buproban, Forfivo XL, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban

When This Medicine Should Not Be Used

How to Use This Medicine

Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may need to take Wellbutrin® for up to 4 weeks before you feel better. You may need to take Zyban® for 1 to 2 weeks before the date that you plan to stop smoking.
  • Swallow the tablet whole. Do not break, crush, divide, or chew it.
  • It is best to take Aplenzin® in the morning.
  • Do not take Wellbutrin® close to bedtime if you have trouble sleeping.
  • You may take this medicine with or without food. If you have nausea, it may help to take it with food.
  • If you use this medicine to prevent depression in seasonal affective disorder, take it during autumn before your symptoms start. Continue using this medicine through the winter season and until early spring.
  • If you take the extended-release tablet, part of the tablet may pass into your stools. This is normal and is nothing to worry about.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine and an MAO inhibitor (MAOI), linezolid, or methylene blue injection within 14 days of each other. Do not use Zyban® to quit smoking if you already take Aplenzin® or Wellbutrin® for depression, because they are the same medicine.
  • Some medicines can affect how bupropion works. Tell your doctor if you are using the following:
    • amantadine, cimetidine, clopidogrel, levodopa, a nicotine patch, tamoxifen, theophylline, ticlopidine
    • blood pressure medicine, insulin or diabetes medicine that you take by mouth, medicine for heart rhythm problems, medicine to treat HIV or AIDS, medicine for seizures, other medicine for depression, medicine to treat mental illness, medicine for anxiety, steroid medicine, or a blood thinner

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, high blood pressure, or low sodium levels. Tell your doctor if you take barbiturates, benzodiazepines, antiepileptic drugs, or sedatives, or if you recently stopped using them. Tell your doctor if you have a history of drug addiction or if you drink alcohol.
  • This medicine may cause the following problems:
    • High risk of seizures
    • Changes in mood or behavior
    • High blood pressure
    • Serious skin reactions
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Zyban® is only part of a complete program to help you quit smoking. You may still want to smoke at times. Have a plan to cope with these situations.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Chest pain, trouble breathing, fast, slow, or uneven heartbeat
  • Muscle or joint pain, fever with rash
  • Restlessness, irritability, nervousness, trouble sleeping, seeing or hearing things that are not there
  • Seizures or tremors
  • Thoughts of hurting yourself, worsening depression, severe agitation or confusion

If you notice these less serious side effects, talk with your doctor:

  • Change in how much or how often you urinate
  • Dry mouth
  • Mild headache or dizziness
  • Nausea, vomiting, constipation, diarrhea, gas, stomach pain
  • Weight gain or loss

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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