Buprenorphine/naloxone (By mouth)


Buprenorphine Hydrochloride (bue-pre-NOR-feen hye-droe-KLOR-ide), Naloxone Hydrochloride (nal-OX-one hye-droe-KLOR-ide)

Treats narcotic medicine dependence.

Brand Name(s)

Suboxone, Zubsolv

When This Medicine Should Not Be Used

How to Use This Medicine

Thin Sheet, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You must let the medicine dissolve under your tongue. Never swallow the film or tablet. Your body may not absorb enough of the medicine if you swallow it.
  • Your health caregiver should show you how to use the medicine. If you do not understand, ask for help. It is important to use the medicine correctly. Do not talk while the medicine is in your mouth.
  • Tablet: Place the tablet under your tongue. If your doctor told you to use more than 1 tablet, place all of the tablets under your tongue together. You can use 2 tablets at a time until you have taken all of the medicine, if that is easier for you. Let the tablets dissolve completely in your mouth. Do not eat or drink anything until the tablets are completely dissolved.
  • Film: Drink water before taking this medicine to help moisten your mouth. Place the film under your tongue. If your doctor told you to use more than 1 film, place the second film on the opposite side from the first one. Do not move the film after you place it under your tongue. If you are supposed to use more than 2 films, use them the same way, but do not start until the first 2 films are completely dissolved.
  • Do not break, crush, chew, or cut the film or tablet.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose:Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Flush any unused Suboxone┬« films and Zubsolv┬« tablets down the toilet.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how buprenorphine/naloxone works. Tell your doctor if you are using the following:
    • Carbamazepine, phenobarbital, phenytoin, or rifampicin
    • A tranquilizer or benzodiazepine (such as alprazolam, clonazepam, diazepam, lorazepam), medicine to treat an infection (such as ketoconazole or erythromycin), or medicine to treat HIV/AIDS (delavirdine, efavirenz, etravirine, nevirapine)
  • Do not drink alcohol while you are using this medicine.
  • Some pain relievers, allergy medicines, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you use any medicine that makes you drowsy.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease (including hepatitis B or C), adrenal gland problems, an enlarged prostate, gallbladder problems, digestion problems, trouble urinating, or low thyroid levels. Tell your doctor if you have any kind of breathing problem, such as COPD or a curved spine that interferes with breathing, or have had a recent head injury, brain tumor, or other problem that could increase the pressure in your head. Tell your doctor if you or a family member has a history of drug or alcohol problems, or if you have any mental or emotional problems.
  • This medicine may cause the following problems:
    • Breathing problems
    • Liver problems
    • Low blood pressure
  • An overdose of this medicine can cause death. Symptoms of overdose include trouble breathing, slow or shallow breathing, severe dizziness or weakness, slow heartbeat, fainting, pinpoint pupils, or severe sleepiness.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.
  • Tell any doctor or dentist who treats you that you are using this medicine.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Lightheadedness, dizziness, or fainting
  • Severe headache
  • Severe stomach pain
  • Trouble breathing, slow or shallow breathing, sighing, extreme weakness or sleepiness

If you notice these less serious side effects, talk with your doctor:

  • Headache, trouble sleeping
  • Mild stomach pain, constipation, or upset stomach
  • Shaking, feeling hot or cold, runny nose, watery eyes, diarrhea, vomiting, and muscle aches
  • Sweating

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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