Bortezomib (Injection)


Bortezomib (bor-TEZ-oh-mib)

Treats multiple myeloma and mantle cell lymphoma.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin or into a vein.
  • You may also receive medicine to help prevent nausea, vomiting, or diarrhea. Ask your doctor if you should drink extra water while you use this medicine. This could help you avoid feeling dizzy or lightheaded.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use medicine to treat HIV or AIDS (such as didanosine, indinavir, lamivudine, nelfinavir, ritonavir, saquinavir, stavudine, zidovudine, Combivir®, Crixivan®, Epivir®, Fortovase®, Invirase®, Kaletra®, Norvir®, or Viracept®), medicine to treat infection (such as clarithromycin, telithromycin, Biaxin®, or Ketek®), medicine to treat a fungus infection (such as itraconazole, ketoconazole, Nizoral®, or Sporanox®), or medicine to treat depression (such as nefazodone or Serzone®).
  • Make sure your doctor knows if you also use St John's wort, medicine to treat tuberculosis (such as rifampin, Rifadin®, Rimactane®), or medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, or Tegretol®).
  • Tell your doctor if you have used any medicine that might cause nerve problems.

Warnings While Using This Medicine

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding or if you have liver disease, heart disease, congestive heart failure, low blood pressure, or a history of fainting. Tell your doctor if you have diabetes, herpes virus infection, lung disease, or nerve problems.
  • Tell your doctor right away if you have burning, numbness, tingling, or painful sensations in your arms, hands, legs, or feet. These could be symptoms of peripheral neuropathy.
  • This medicine can lower your blood pressure too much and cause you to feel lightheaded, dizzy, or tired. This is more likely to happen if you use medicines that affect you blood pressure or are dehydrated. Stand or sit up slowly if you are dizzy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may cause serious heart problems. Tell your doctor right away if you have chest pain, trouble breathing, uneven heartbeat, or swelling of the feet, ankles, or legs.
  • This medicine may increase your chance of having a brain condition called reversible posterior leukoencephalopathy syndrome (RPLS). Check with your doctor right away if you have headaches, seizures, extreme drowsiness, confusion, or vision changes.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how often you urinate, rapid weight gain, stomach or joint pain, or swelling of the feet or lower legs.
  • If you are diabetic and you take an oral antidiabetic medicine, you should check your blood sugar level often and report any unusual changes to your doctor.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate, painful or difficult urination
  • Chest pain or fast, slow, or uneven heartbeat
  • Confusion or seizures
  • Dark-colored urine or pale stools
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Severe diarrhea, nausea, vomiting, or stomach pain
  • Sudden or severe headache, or problems with vision, speech, or walking
  • Swelling in your face, arms, legs, ankles, or feet
  • Trouble breathing
  • Unusual bleeding, bruising, tiredness, or weakness
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Loss of appetite
  • Mild diarrhea, constipation, nausea, or vomiting
  • Mild headache
  • Mild skin rash or itching
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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