Boceprevir (By mouth)


Boceprevir (boe-SE-pre-vir)

Treats hepatitis C.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed.
  • Use all of the medicines your doctor has prescribed to treat hepatitis C infection. Boceprevir by itself will not treat hepatitis C.
  • It is best to take this medicine with food or milk.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If it is less than 2 hours before your next dose, wait until then to take the medicine and skip the missed dose. If it is more than 2 hours before your next dose, take the missed dose. Then take the next dose as scheduled. Ask your pharmacist or doctor if you have any questions about this.
  • Store the medicine in a closed container in the refrigerator. You may also store it at room temperature, away from heat, moisture, and direct light, for up to 3 months.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with St John's wort, alfuzosin, carbamazepine, cisapride, doxazosin, drospirenone, lovastatin, oral midazolam, phenobarbital, phenytoin, pimozide, rifampin, sildenafil, silodosin, simvastatin, tadalafil, tamsulosin, triazolam, or ergot medicines.
  • Some medicines can affect how boceprevir works. Tell your doctor if you are taking any of the following:
    • Alprazolam, bosentan, clarithromycin, colchicine, desipramine, digoxin, escitalopram, methadone, midazolam injection, rifabutin, salmeterol, trazodone
    • Medicine to lower cholesterol (such as atorvastatin, pravastatin), medicine that suppresses the immune system (such as cyclosporine, sirolimus, tacrolimus), medicine for heart rhythm problems, blood pressure medicine (a calcium channel blocker), medicine to treat a fungus infection, medicine to treat HIV or AIDS, medicine to treat impotence, a steroid medicine (such as dexamethasone, fluticasone, prednisone), a blood thinner (such as warfarin), or birth control pills

Warnings While Using This Medicine

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. You must use 2 forms of birth control to prevent pregnancy during treatment and for 6 months after treatment ends.
  • Tell your doctor if you are breastfeeding, or if you have other liver problems or HIV infection. Tell your doctor if you plan to have surgery.
  • This medicine may cause the following problems:
    • Anemia
    • Low blood cell counts, which may lead to severe infections
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Fever, chills, cough, sore throat, and body aches
  • Pale skin, trouble breathing, dizziness or fainting, unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Change or loss of taste, decreased appetite
  • Diarrhea, nausea, vomiting
  • Tiredness or joint pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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