Treats cancer, including colorectal cancer, glioblastoma, and some forms of lung cancer.
When This Medicine Should Not Be Used
How to Use This Medicine
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
- Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Warnings While Using This Medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use 2 forms of birth control to prevent pregnancy while you are using this medicine. Keep using 2 forms of birth control for at least 6 months after your treatment ends.
- Talk with your doctor if you plan to have children. Some women are not able to get pregnant after they have used this medicine.
- Tell your doctor if you are breastfeeding, or if you have blood pressure problems, heart disease, a history of heart attack or stroke, or bleeding problems or blood clots.
- This medicine may cause the following problems:
- A hole in your digestive system
- High blood pressure
- Increased risk for bleeding problems or blood clots
- Infusion reaction
- Nervous system damage
- This medicine may affect the way your body heals. Tell any doctor who treats you that you are using this medicine. You may need to stop using it several weeks before and after surgery.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
- Your doctor will need to check your urine and blood pressure at regular visits while you are receiving this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bleeding from your rectum, or black, tarry stools
- Chest pain or coughing up blood
- Constipation, stomach pain, nausea, or vomiting
- Fever, chills, trouble breathing, fainting, or chest pain within a few hours after you receive this medicine
- Menstrual periods stop
- Numbness or weakness in your arm or leg, or on one side of your body
- Pain in your calf
- Seizure, confusion, or unusual drowsiness
- Sudden or severe headaches, or problems with vision, speech, or walking
- Swollen hands, ankles, or feet
- Tingling or burning pain in your hands, arms, legs, or feet
- Trouble breathing, cold sweats, and bluish skin
- Trouble swallowing, or coughing or choking while you eat
- Unusual bleeding, bruising, or weakness, nosebleeds
- Vomiting blood or material that looks like coffee grounds
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, loss of appetite, stomach pain, unusual taste
- Tiredness or weakness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 8/4/2014
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.