Betamethasone sodium phosphate/betamethasone acetate (Injection)


Betamethasone Acetate (bay-ta-METH-a-sone AS-e-tate), Betamethasone Sodium Phosphate (bay-ta-METH-a-sone SOE-dee-um FOS-fate)

Treats inflammation and many other medical problems. This medicine is a corticosteroid.

Brand Name(s)

Celestone Soluspan

When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • A nurse or other trained health professional will give you this medicine.
  • This medicine is given as a shot into your muscle, a joint (such as a knee or shoulder), or into your skin.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Use a new needle and syringe each time you inject your medicine.

If a dose is missed:

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

How to Store and Dispose of This Medicine

  • If you store this medicine at home, keep it at room temperature, away from heat and direct light.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.
  • Make sure your doctor knows if you are taking medicine that weakens your immune system (such as steroids, chemotherapy, or radiation).
  • Make sure your doctor knows if you are on combination therapy of medicine for tuberculosis (TB) and steroids. Tell your doctor if you are using aspirin.
  • Make sure your doctor knows if you take aspirin on a regular basis.
  • You may need to be on salt restricted diet and on salt substitutes that contain potassium. Talk to your doctor about this.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • It may be easier for you to get an infection while using this medicine. Avoid people who are sick or have infections. If you are exposed to chickenpox or measles, tell your doctor right away.
  • Make sure your doctor knows if you have any events causing unusual stress or anxiety in your life. Your dose of this medicine may need to be changed during times of stress.
  • This medicine may cause problems if you have many medical conditions. Make sure your doctor knows if you have had any allergies, medical problems, or mental conditions.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Black or tarry stools.
  • Blurred vision, pain or watering in your eyes.
  • Muscle weakness or cramps.
  • Sore throat, high fever, or trouble swallowing.
  • Bluish-colored skin.
  • Seizures.
  • Sudden and severe stomach pain, nausea, vomiting.
  • Unusual bleeding or bruising.

If you notice these less serious side effects, talk with your doctor:

  • Dizziness or headache.
  • Dry mouth, increased thirst.
  • Gaining weight around your neck, upper back, breast, face or waist.
  • Increased sweating.
  • Irregular menstrual periods.
  • Mood changes, depression or trouble sleeping.
  • Pain, swelling, or stiffness in your joints.
  • Redness of your face.
  • Swelling in your hands, ankles or feet.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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