Asenapine (By mouth)


Asenapine (a-SEN-a-peen)

Treats schizophrenia and bipolar disorder.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Dry your hands before you handle the tablet.
  • Do not open the blister pack that contains the tablet until you are ready to take the medicine. Peel back the foil. Then remove the tablet. Do not push the tablet through the foil.
  • Do not crush, chew, or swallow the tablet. Place the tablet under your tongue and let it melt.
  • Do not eat or drink anything for at least 10 minutes after you take this medicine.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines and foods can affect how asenapine works. Tell your doctor if you are taking any of the following:
    • Blood pressure medicine
    • Fluvoxamine, paroxetine
    • Heart rhythm medicine, such as amiodarone, procainamide, quinidine, sotalol
    • Infection medicine, such as gatifloxacin, moxifloxacin
    • Medicine to treat mental illness, such as chlorpromazine, thioridazine, ziprasidone
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, diabetes, trouble swallowing, or a history of seizures or neuroleptic malignant syndrome (NMS). Tell your doctor if you have a blood vessel or heart problem, including low blood pressure, heart failure, heart rhythm problems (such as QT prolongation, slow heartbeat), low potassium or magnesium levels, or a history of a heart attack or stroke.
  • This medicine may cause the following problems:
    • Agitation, irritability, depression, suicidal thoughts, or other abnormal behaviors
    • A serious condition called neuroleptic malignant syndrome (NMS)
    • Heart rhythm changes, such as QT prolongation
    • Tardive dyskinesia (a movement disorder) that may not go away after you stop taking this medicine
  • Asenapine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly. You may feel lightheaded if you get up suddenly from a lying or sitting position.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • You might get overheated while you are taking this medicine. Drink more water during hot weather, and while you exercise. Call your doctor if you are too hot and cannot cool down.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate
  • Fast, slow, pounding, or uneven heartbeat
  • Fever, confusion, increased sweating, severe muscle stiffness, or loss of bladder control
  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw)
  • Lightheadedness, dizziness, or fainting
  • Mood or behavior changes, or thoughts of hurting yourself or others
  • Problems with balance or walking
  • Seizures, unusual tiredness or weakness, pale skin
  • Shortness of breath or trouble breathing
  • Swelling in your hands, ankles, feet, or breasts
  • Trouble speaking or sleeping
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Drooling, constipation, vomiting, stomach pain, or upset stomach
  • Joint or muscle pain
  • Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 8/4/2014

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